Objectives:

1. Describe the pentose phosphate pathway

Names:
Functions:
Substrates:

Product:
Control Enzymes:
Regulation:
Compartment(s):
Tissues of interest:
2. If a cell needs both NADPH and ribose-5-phosphate, what substrate from glycolysis is used by the pentose phosphate pathway to make them? If a cell needs only ribose-5-phosphate what substrates from glycolysis are used by the pentose phosphate pathway?
3. What is NADPH used for?
4. Assume that you have a patient that has hemolytic anemia a result of eating fava beans. Name the deficient enzyme and the other enzymes and products in the pathway that leads to the reduction of HOOH.
5. Concerning Al Martini: This patient has glucose-6-phosphate dehydrogenase deficiency. Why are red blood cells lysed while other cells of the body remain intact? Why didn't this disease show up earlier in life?

Keywords:

anabolic pathway, antimalarial drugs, biosynthesis, cytosol, detoxification, fava beans, fructose-6-phosphate, glucose-6-phosphate, glucose-6-phosphate dehydrogenase, glutathione, glutathione peroxidase, glutathione reductase, glyceraldehyde-3-phosphate, glycolysis, H2O2, hexose monophosphate shunt, irreversible, NADPH, nonoxidative, oxidative, oxidized glutathione, pentose phosphate pathway, 6-phosphogluconate dehydrogenase, reduced glutathione, reductive biosynthesis, reversible, ribose-5-phosphate, pentose phosphate pathway, peroxide, primaquine, product inhibition, reactive oxygen species (ROS), sulfa drugs, sulfhydryl group, superoxide ion, vitamin C, vitamin E.

Assignments:

Understand the meaning of the key words in the context of Chapter 29.

Only Section C. The Pentose Phosphate Pathway and Al Martini are assigned.

Examine the Question (Q:) and Answer (A:) on page 546 in Chapter 29.

Work Review Questions 3, but not 1, 2, 4, and 5 at the end of the Chapter 29.

Work the Practice Questions for Chapter 29 Objectives

Other Help:

Here is my answer to the Q: and A: on page 546