David James Mokler, Ph.D

Department of Pharmacology

University of New England
College of Osteopathic Medicine
11 Hills Beach Road
Biddeford, Maine 04005

(207) 283-0171 Ext. 2210

dmokler@mailbox.une.edu

Education and Training
1984 - 1986 Postdoctoral Fellow, Medical College of Virginia, Virginia Commonwealth University, Department of Pharmacology and Toxicology, Richmond, Virginia
SPONSOR: Dr. John A. Rosecrans
1979 - 1984 Ph.D., Michigan State University, Department of Pharmacology and Toxicology, and Neurosciences Program (Dual Doctorate), East Lansing, Michigan
ADVISOR: Dr. Richard H. Rech
1969 - 1973 B.S., Michigan State University, E. Lansing, Michigan
MAJOR: Psychology

Academic Appointments
2000- present Professor of Pharmacology (tenure 1993)
University of New England
College of Osteopathic Medicine
1999-present Adjunct Professor
Center for Behavioral Development and Mental Retardation
Department of Psychiatry
Boston University School of Medicine
July, 1999-Jan., 2000 Visiting Professor (Sabbatical from UNE)
Center for Behavioral Development and Mental Retardation
Department of Psychiatry
Boston University School of Medicine
1990 - 2000 Associate Professor of Pharmacology (tenure 1993)
University of New England
College of Osteopathic Medicine
1986 - 1990 Assistant Professor of Pharmacology
University of New England
College of Osteopathic Medicine

Selected Publications

  1. Anderson, M.F., Mokler, D.J. and Winterson, B.J. Inhibition of chronic hindlimb flexion in rat: Evidence for mediation by 5-hydroxytryptamine. Brain Research 541, 216-224, 1991.
  2. Mokler, D.J., Sullivan, S.A., and Winterson, B.J. Behaviors induced by 5-hydroxytryptophan in neonatal, preweaning and postweaning rats. Pharmacol. Biochem. Behav. 42: 413-419, 1992.
  3. Moore, R.W., Mokler, D.J. and Winterson, B.J. Intrathecally administered N-methyl-D-aspartate increases persistent hindlimb flexion in rat. Neuroscience Letters 146: 223-226, 1992.
  4. Mokler, D.J., Dixon, M. and Stambaugh, L. Discrimination of electrical stimulation of the dorsal raphe nucleus in rats using a discriminated taste aversion paradigm. Pharmacology, Biochemistry and Behavior, 48: 1041-1045, 1994.
  5. Yonuschot, G., Mokler, D.J. and Winterson, B.J. A hypothesis for the facilitated segment based upon biological principles associated with tumorigenesis. American Academy of Osteopathy Journal 4 (4): 9-28, 1994.
  6. Mokler, D.J., Abbruzzee, S., Trumble, V., and Whitten, B. Effects of ketanserin on the discrimination of electrical stimulation of the dorsal raphe nucleus in rats. Neuropharmacol. 36(4/5):631-636, 1997.
  7. Ally, A., Caringi, D., Koester, D.M., Kobayashi, T. and Mokler, D.J. Central 5-HT1A modulation of cardiovascular responses to tibial nerve stimulation-evoked muscle contraction. Am. J. Physiol. 272: R1020-R1027, 1997.
  8. Asmundsson G., Caringi D.C., Mokler D.J., Kobayashi T., Ishide T., and Ally A.: Extracellular serotonin changes in VLM during muscle contraction: Effects of 5-HT1A-receptor activation. Am J Physiol.: 273(6 Pt 2):H2899-909, 1997.
  9. Bronzino, J.D., Austin-LaFrance, R.J., Mokler, D. and Morgane, P.J. Effects of prenatal malnutrition on hippocampal long-term potentiation in freely moving rats. Exper. Neurol. 148: 317-323, 1997.
  10. Kobayashi, T., Caringi, D.C., Mokler, D.J., and Ally, A.: Effects of rostral or caudal ventral medullary AMPA receptor antagonism on the pressor response to muscle contraction. American Journal of Physiology: Heart and Circulatory Physiology 271:H2774-H2781, 1997.
  11. Caringi D.C., Mokler D.J., Koester D., and Ally A. Rostral vetrolateral medullary opioid receptor stimulation modulates pressor response during isometric muscle contraction. American Journal of Physiology: Heart and Circulatory Physiology 274(1 Pt 2):H139-46, 1998.
  12. Mokler, D.J., Larevierre, D., Johnson, D.W., Theriault, N.L., Dixon, M., and Morgane, P.J. 5-hydroxy- tryptamine neuronal release from dorsal hippocampus following electrical stimulation of the dorsal and median raphé nuclei in the conscious rat. Hippocampus 8(3): 262-73, 1998.
  13. Asmundsson, G., Mokler, D.J., Ally, A. Effects of ventrolateral medullary NMDA-receptor antagonism on biogenic amines and pressor response to muscle contraction. Neurosci. Res.; 32(1):47-56, 1998.
  14. Bronzino, J.D., Blaise, J.H., Mokler, D.J., and Morgane, P.J. Dentate granule cell modulation in freely moving rats: Vigilance state effects. Dev. Brain Res.; 114(1):143-148, 1999.
  15. Mokler, D.J., Bronzino, J.D., Galler, J.R. and Morgane, P.J. The effects of median raphé electrical stimulation on serotonin release in the dorsal hippocampal formation of prenatally protein malnourished rats. Brain Res. 838:95-103.
  16. J. D. Bronzino, J. H. Blaise, D. J. Mokler, J. R. Galler, and P. J. Morgane. Modulation of paired-pulse responses in the dentate gyrus: effects of prenatal protein malnutrition. Brain Res. 849 (1-2):45-57, 1999.
  17. Johnson, D.W., Eodice, P., Winterbottom, H. and Mokler, D.J. Increases in extracellular dopamine release in the nucleus accumbens after acute cocaine are not required for expression of behavioral sensitization in female Sprague-Dawley rats. Pharmacology, Biochemistry and Behavior, 65 (4): 659-664, 2000.
  18. Mokler, D.J., Clayton, N.P., Field, S., Mastalong, H., Stadig, S., and Dixon, M. Discrimination of the 5- HT2 agonist DOI: Generalization to electrical stimulation of the dorsal raphe nucleus in rats. In preparation
  19. Mokler, D.J. and Hay, T. Effects of chronic haloperidol on mesocortical, mesolimbic and nigrostriatal dopamine systems following acute or chronic stress. In preparation.