Amy J. Davidoff, Ph.D
Research Support
Research Support
RESEARCH SUPPORT: (Recent)
7-04-RA-23 |
Davidoff (PI) | 07/01/04 - 6/30/07 |
Title: Link between myocardial insulin resistance and abnormal excitation-contraction coupling
Research designed to determine whether there is a link between the pathogenesis of cellular insulin resistance and abnormal excitation-contraction coupling induced by abnormal metabolism of glucose and fatty acids. Animal models of type 1 and type 2 diabetes will be utilized in addition to primary cultures of adult ventricular myocytes, to determine whether there is a convergence of intracellular signals (e.g., PKC) stimulated by both glucose and fatty acids.
Role: PI
Pilot Study |
Davidoff (PI) | 2006 |
Title: Efficacy of blueberry, Vaccinium angustifolium, extracts in treating diabetes-induced metabolic complications
The primary objective of this investigation is to measure the effects of water-based extracts from the low bush blueberry on the metabolic status of animal models for type 2 diabetes. Initial studies will be conducted to determine whether whole berry extracts can prevent/reverse insulin sensitivity in a diet-induced rodent model of early stage type 2 diabetes. Blood glucose, insulin and lipid levels will be used as indices for establishing initial treatment durations and doses, and to guide subsequent longitudinal studies involving pro-inflammatory profiles.
Role: PI
R01 HL66895 |
Davidoff (PI) | 09/01/00 - 8/31/06 |
Title: Diabetic cardiomyopathy - role of insulin resistance
Research designed to determine whether there are converging intracellular pathways associated with the development of myocardial insulin resistance and abnormal cardiac E-C coupling in early stages of the development of type 1 and type 2 diabetic cardiomyopathy.
Role: PI