Amy J. Davidoff, Ph.D

Publications

PUBLICATIONS:

Fülöp N, Mason MM, Dutta K, Want P, Davidoff AJ, Marchase RB,
Chatham JC.  (2007) The impact of type-2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart.  Am J Physiol Cell Physiol 292:C1370-1378.

Schwanke ML, Dutta K, Podolin DA, Davidoff AJ. (2006) Cardiomyocyte dysfunction in insulin resistant rats: a female advantage.  Diabetologia 49:1097-1105.

Davidoff AJ (2006)  Convergence of glucose- and fatty acid-induced abnormal myocardial E-C coupling and insulin signalling.  Clin Exp Pharm Physiol 36:152-158.

Wold LE, Dutta K, Mason MM, Ren J, Cala SE, Schwanke ML, Davidoff AJ (2005) Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats.  J Mol Cell Cardiol 39:297-307.

Davidoff AJ, Davidson MB, Carmody MW, Davis ME, Ren J (2004) Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: Role of glucose-induced PKC activity.  Mol Cell Biochem 262:155-163.

Davidoff AJ, Mason MM, Davidson MB, Carmody MW, Hintz K, Wold LE, Podolin DA, Ren J (2004) Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments.  Am J Physiol Endo and Metab 286:E718-E724.

Dutta K, Carmody MW, Cala SE, Davidoff AJ (2002) Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy. J Mol Cell Cardiol 34:985-996.

Ren J, Davidoff AJ (2002)  α2-Heremans Schmid Glycoprotein, a putative inhibitor of tyrosine kinase, prevents glucose toxicity associated with cardiomyocyte dysfunction. Diabetes and Metabolism, 18:305-310.

Dutta K, Podolin DA, Davidson MB, Davidoff AJ (2001) Cardiomyocyte dysfunction in sucrose-fed rats is associated with insulin resistance.  Diabetes  50:1186-1192.

Kim CS, Davidoff AJ, Maki TM, Doyle AA, Gwathmey JK (2000)  Intracellular calcium and the relationship to contractility in an avian model of heart failure.  J Comp Physiol B 170: 295-306.

Ren J, Dominguez LJ, Sowers JR, Davidoff AJ (1999)  Metformin but not glyburide prevents high glucose-induced abnormalities in relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes.  Diabetes48:2059-2065.

Davidoff AJ, Walsh MF, Marsh JD, Sowers JR (1998)  Abnormalities of cardiovascular calcium metabolism associated with diabetes mellitus and metabolic hypertension.  In:  Calcium antagonists in clinical medicine.  ed. M. Epstein, 2nd edition, Hanley & Belfus, Inc., Philadelphia, PA, pp. 27-34.
Ren J, Gintant GA, Miller RE, Davidoff AJ (1997)  High extracellular glucoseimpairs cardiac E-C coupling in a glycosylation-dependent manner. Am J Physiol  273:H2876-H2883.

Ren J, Davidoff AJ, Brown RA (1997) Acetaldehyde depresses shortening and intracellular Ca2+ transients in adult rat ventricular myocytes.  Cell Mol Biol  43:825-834.

Davidoff AJ, Maki TM, Ellingsen Ø, Marsh JD (1997)  Expression of calcium channels in the adult heart is regulated by calcium.  J Mol Cell Cardiol  29:1791-1803.

Davidoff AJ, Ren J (1997)  Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes.  Am J Physiol  272:H159-H167.

Ren J, Davidoff AJ (1997)  Diabetes rapidly induces contractile dysfunction in isolated ventricular myocytes.  Am J Physiol  272:H148-H158.

Ren J, Dominguez LJ, Sowers JR, Davidoff AJ (1996)  Troglitazone attenuates high glucose-induced abnormalities in relaxation and intracellular calcium in rat ventricular myocytes.  Diabetes  45:1822-1825.

Maki TM, Gruver J, Davidoff AJ, Izzo N, Toupin D, Colucci W, Marks A, Marsh JD (1996)  Regulation of calcium channel expression in neonatal myocytes by catecholamines.  J Clin Invest  97:656-663.

Dominguez LJ, Davidoff AJ, Srinivas PR, Standley PR, Walsh MF, Sowers JR  (1996)  Effects of metformin on tyrosine kinase activity, glucose transport and intracellular calcium in rat vascular smooth muscle.  Endocrinology  137:113-121.

Balligand JL, Ungureanu-Longrois D, Simmons W, Pimental D, Malinski TA, Kapturczak M, Taha Z, Lowenstein CL, Davidoff AJ, Kelly RA, Smith TW, Michel T (1994)  Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes:  Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.  J Biol Chem  269:27580-27588.

Gwathmey JK, Davidoff AJ (1994)  Pathophysiology of cardiomyopathies. Part II:  Drug-induced and other interventions.  Current Opinion inCardiology  9:369-378.

Davidoff AJ, Gwathmey JK (1994)  Pathophysiology of cardiomyopathies. Part I:  Animal models and humans.  Current Opinion in Cardiology  9:357-368.

Berger HJ, Prasad SK, Davidoff AJ, Ellingsen Ø, Marsh JD, Smith TW, Kelly RA, (1994)  Continual uniform electric field stimulation preserves contractile function of adult rat ventricular myocytes in primary culture.  Am J Physiol  266:H341-H349.

Ellingsen Ø, Davidoff AJ, Prasad SK, Berger HJ, Springhorn JP, Marsh JD, Kelly RA, Smith TW (1993)  Adult rat ventricular myocytes cultured in defined medium:  Phenotype and electromechanical function.  Am J Physiol265:H747-H754.

Gwathmey JK, Davidoff AJ (1993)  Experimental aspects of cardiomyopathies. Current Opinion in Cardiology  8:480-495.

Katzka D, Cox RH, Davidoff AJ, Morad M (1992)  Cation selectivity of calcium channel in portal vein myocytes.  Am J Physiol 262:H326-330.

Rodgers RL, Davidoff AJ, Mariani MJ (1991)  Cardiac function of the diabetic renovascular hypertensive rat: effects of insulin and thyroid hormone treatment.  Can J Physiol Pharmacol  69:346-354.

Davidoff AJ, Pinault FM, Rodgers RL (1990)  Ventricular relaxation of diabetic spontaneously hypertensive rat.  Hypertension  15:643-651.

Davidoff AJ, Rodgers RL (1990)  Insulin, thyroid hormone and heart function of diabetic spontaneously hypertensive rat.  Hypertension  15:633-642.